The Effects of Cyclosporine and Tacrolimus on Gingiva and Alveolar Bone of Rats

Objective: Cyclosporine A (CsA) and tacrolimus (Tac) are immunosuppressive drugs which is frequently used in organ transplantation. CsA can cause various side effects including gingival overgrowth (GO) osteopenia. Tac has similar to but with different incidences. The aim of the present study was evaluate compare on GO alveolar bone resorption rats.
 Methods: Sixty mature male rats were randomly equally allocated into six groups, as follows: Control-I, Control-II, CsA-I, CsA-II, Tac-I Tac-II. Control-I Control-II groups received, subcutaneously, 1 ml/kg 0.9% NaCl, while CsA-I CsA-II received 10 mg/kg daily, Tac-II 1.5 daily. sacrificed 16th day other 31st day. Histological histomorphometric analysis buccal gingiva tartrate-resistant acid phosphatase (TRAP) enzyme histochemistry performed right mandibular segment each animal. 
 Results: significantly greater administered compared (P0.05). caused a significant increase TRAP positivity Conclusions: Our results showed that does not seem resorption. However, deleterious tissues may be time-related.